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Blind calcium supplementation increases the risk of bowel cancer

 A recent study published by scientists at the University of North Carolina found that calcium supplementation (or combined with vitamin D supplementation) may significantly increase the risk of colorectal cancer precancerous polyps in middle-aged and elderly people.

Calcium supplementation increases the risk of precancerous polyps in bowel cancer

A total of 2058 subjects were included in this study, aged 45 to 75 years. All subjects had at least one adenomatous polyp removed under colonoscopy 4 months before the start of the study, and follow-up colonoscopy follow-ups have been arranged . The study randomly divided all subjects into 4 treatment groups: calcium supplementation alone group, vitamin D supplementation group alone, calcium and vitamin D supplementation group at the same time, and no calcium and vitamin D supplementation group. The calcium supplement dosage is 1200 mg/day, and the vitamin D supplement dosage is 1000 IU/day.

The above calcium and/or vitamin D should be terminated 3 to 5 years after treatment, and then colonoscopy should be performed. Then enter the observation period, that is, the study is based on observation and follow-up. During this period, calcium and vitamin D supplementation will not be given. Observe for at least 3 years, and then perform colonoscopy again. The scientists then analyzed the data collected during the treatment period and the observation period to evaluate the effect of calcium or vitamin D supplementation on the risk of colorectal serrated polyps (especially sessile serrated polyps). This kind of polyps is just one of the precancerous lesions of colorectal cancer.

The results showed that during the observation period, calcium supplementation alone increased the risk of sessile serrated adenoma/polyp by 1.65 times, while the risk of combined vitamin D supplementation group increased by 2.81 times, and the risk of vitamin D supplementation alone group did not increase significantly. From the results of other subtypes (dentate polyps, hyperplastic polyps), whether it is calcium supplementation alone, vitamin D supplementation alone, or calcium supplementation + vitamin D supplementation, there is no significant effect.

Calcium supplementation for healthy people also needs to follow the doctor's advice

Studies have found that calcium supplementation or combined vitamin D supplementation can increase the risk of sessile serrated adenomas/polyps, but this effect is a delayed effect, which only appears 6 to 10 years after calcium or vitamin D supplementation.

So, if we lack calcium, can we still supplement calcium? This study is aimed at people who have had colorectal adenomas in the past, so its results cannot be generalized to healthy people, so healthy people who are taking calcium and/or vitamin D for a long time need not worry too much. But the premise is to follow the guidance of clinicians.

Teng Xiao, director of the Department of Orthopaedics, Taizhou Central Hospital, said that many people equate osteoporosis with calcium deficiency. They think that calcium supplementation is necessary for osteoporosis. The more calcium supplementation, the more absorption, and the formation of bones The more, so I desperately replenish calcium. In fact, this concept is wrong. Even for elderly people over 60 years old, 800 mg of calcium per day is sufficient. Excessive calcium supplementation will not only strengthen bones, but will cause complications and endanger human health. In addition, different groups of people have different calcium supplement dosages and methods, and you must not blindly supplement calcium by yourself.

Patients with intestinal polyps can reasonably supplement calcium according to their own conditions

So, for people with colorectal adenomas like the subjects in this study, is it not recommended to supplement calcium and/or vitamin D? This is not necessarily the case. The calcium dose used in this study is higher than the calcium content in the commonly taken multivitamin preparations. Therefore, for people with colorectal adenoma, it is necessary to comprehensively consider the specific situation of the individual and weigh the pros and cons to decide whether to continue calcium and (or vitamin D) supplementation.

If polyps are exposed to various stimuli in the colon for a long time, they are very prone to cancer. The typical early symptoms are diarrhea, and some people will experience abdominal pain, anemia, weight loss, and excretion disorders. If they have not been treated, they may also have pus and blood in the stool. Therefore, patients with intestinal polyps should pay attention to maintaining a healthy lifestyle to prevent disease progression. Smoking and excessive alcohol consumption increase the risk of colon polyps and colon cancer. Women should not drink more than 150 ml of wine, or 360 ml of beer, or 40 ml of liquor a day, while men should not exceed twice that of women. If you have a family history of colon cancer, you should especially reduce smoking and drinking to reduce the risk of disease

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